Detecting autocatalytic, self-sustaining sets in chemical reaction systems

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Detecting autocatalytic, self-sustaining sets in chemical reaction systems.

The ability of systems of molecular reactions to be simultaneously autocatalylic and sustained by some ambient 'food source' of simple molecules may have been an essential step in the origin of life. In this paper we first describe a polynomial-time algorithm that determines whether any given set of molecules, reactions and catalysations contains a subsystem that is both autocatalytic and able ...

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Given any finite and closed chemical reaction system, it is possible to efficiently determine whether or not it contains a ‘self-sustaining and collectively autocatalytic’ subset of reactions, and to find such subsets when they exist. However, for systems that are potentially open-ended (for example, when no prescribed upper bound is placed on the complexity or size/length of molecules types), ...

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Required Levels of Catalysis for Emergence of Autocatalytic Sets in Models of Chemical Reaction Systems

The formation of a self-sustaining autocatalytic chemical network is a necessary but not sufficient condition for the origin of life. The question of whether such a network could form "by chance" within a sufficiently complex suite of molecules and reactions is one that we have investigated for a simple chemical reaction model based on polymer ligation and cleavage. In this paper, we extend thi...

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Tractable models of self-sustaining autocatalytic networks

Self-sustaining autocatalytic networks play a central role in living systems, from metabolism at the origin of life, simple RNA networks, and the modern cell, to ecology and cognition. A collectively autocatalytic network that can be sustained from an ambient food set is also referred to more formally as a ‘Reflexively Autocatalytic F-generated’ (RAF) set. In this paper, we first investigate a ...

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ژورنال

عنوان ژورنال: Journal of Theoretical Biology

سال: 2004

ISSN: 0022-5193

DOI: 10.1016/j.jtbi.2003.11.020